Mucus secretion

Across TCGA cell cohorts, RNA activity of the Mucus secretion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASL, HIVEP1, and ACAD10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mucus secretion activity versus ASL in LUNG_NSCLC_LUAD (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ASL →	+1.464	+0.287	.001	.006	3	3
STOMACH	HIVEP1 →	-1.007	-0.283	.006	.009	3	3
OESOPHAGUS	ACAD10 →	-1.094	-0.437	.003	<.001	3	3
LUNG_NSCLC_LUAD	LAT2 →	+2.678	+0.305	.001	.007	3	2
LUNG_NSCLC_LUAD	TMPRSS11E →	+3.582	+0.386	<.001	.001	3	2
BREAST	ZNF207 →	-0.758	-0.323	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070254 vs ASL — LUNG_NSCLC_LUAD

Explore this scatter interactively →