Negative regulation of thymocyte apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of thymocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ETF1, NOP16, and NCBP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ETF1 grouped by Negative regulation of thymocyte apoptotic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ETF1 →	+0.559	+1.065	.001	<.001	3	4
LUNG_NSCLC_LUAD	NOP16 →	+0.462	+0.780	.002	.006	3	4
BLOOD_Myeloma	NCBP2 →	+0.625	+1.568	.005	.001	3	4
BLOOD_Myeloma	MTERF3 →	+1.917	+1.589	<.001	.003	2	5
BLOOD_Leukemia	UBIAD1 →	+0.509	+0.978	<.001	.002	3	4
LARGE_INTESTINE	VPS26C →	+0.417	+1.040	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ETF1 by Negative regulation of thymocyte apoptotic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →