Negative regulation of thymocyte apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of thymocyte apoptotic process pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGO1, SPTBN5, and WDR33, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGO1 grouped by Negative regulation of thymocyte apoptotic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	AGO1 →	+0.238	+1.528	.001	<.001	3	3
SOFT_TISSUE	SPTBN5 →	+0.167	+1.431	.001	.002	2	4
OESOPHAGUS	WDR33 →	+0.278	+1.496	<.001	<.001	3	3
OESOPHAGUS	CACNA1C →	-0.114	-1.188	.002	.002	3	3
PANCREAS	TFRC →	+0.628	+1.489	<.001	<.001	3	3
BLOOD_Myeloma	MICAL2 →	+0.296	+1.843	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGO1 by Negative regulation of thymocyte apoptotic process activity — OVARY

Explore this box plot interactively →