Regulation of thymocyte apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of thymocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GDF15, FDXR, and PHLDA3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GDF15 grouped by Regulation of thymocyte apoptotic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GDF15 →	-4.074	-1.550	<.001	<.001	3	7
STOMACH	FDXR →	-1.808	-2.040	<.001	<.001	3	7
OVARY	PHLDA3 →	-2.491	-1.487	<.001	<.001	3	7
OVARY	RPS27L →	-1.347	-1.040	<.001	<.001	3	7
SOFT_TISSUE	CDC25C →	+0.848	+1.733	<.001	<.001	3	6
STOMACH	MDM2 →	-1.908	-1.953	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GDF15 by Regulation of thymocyte apoptotic process activity — SKIN

Explore this box plot interactively →