Regulation of thymocyte apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of thymocyte apoptotic process pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP9X, KCNIP3, and RAB14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, USP9X grouped by Regulation of thymocyte apoptotic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	USP9X →	+0.308	+0.155	.007	.003	3	4
BLOOD_Lymphoma	KCNIP3 →	+0.314	+0.257	.008	.005	3	4
BLOOD_Lymphoma	RAB14 →	-0.500	-0.347	<.001	.007	3	4
STOMACH	AK3 →	-0.137	-0.194	.002	<.001	3	4
BLOOD_Leukemia	RAB18 →	-0.290	-0.160	<.001	.007	3	3
STOMACH	FOXF2 →	-0.288	-0.243	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

USP9X by Regulation of thymocyte apoptotic process activity — PANCREAS

Explore this box plot interactively →