Thymocyte apoptotic process

pathway activity — cross-omics
GO:0070242Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Thymocyte apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADA, FN1, and THBS2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADADA →+0.514+0.041<.001<.00138
BRCAFN1 →+0.575+0.043<.001<.00138
COADTHBS2 →+1.010+0.030<.001<.00137
GBMCTHRC1 →+0.853+0.078<.001<.00137
GBMPLOD1 →+0.623+0.058<.001.00137
COADAPOE →+0.560+0.027<.001<.00137
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration