Thymocyte apoptotic process

pathway activity — cross-omics
GO:0070242Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Thymocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THOC5, JARID2, and IL20RA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCTHOC5 →+0.576+1.202<.001<.00134
PDACJARID2 →+0.278+0.498.008.00334
GBMIL20RA →-0.565-0.578.009.00534
BRCAUBXN10 →-1.200-0.773<.001<.00134
LSCCVANGL2 →+1.033+0.972.001<.00134
BRCASNHG17 →+0.271+0.588.006.00234
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration