Positive regulation of T cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of T cell apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMSN1_S23, SEPTIN1, and SERPINB9, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell apoptotic process activity versus SAMSN1_S23 in BRCA (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SAMSN1_S23 →	+0.958	+0.055	<.001	.003	3	10
GBM	SEPTIN1 →	+0.982	+0.090	<.001	<.001	3	10
COAD	SERPINB9 →	+0.554	+0.066	<.001	<.001	3	10
GBM	SKAP2 →	+0.705	+0.097	<.001	<.001	3	10
HNSC	STAT2 →	+0.433	+0.080	<.001	<.001	3	10
LSCC	STK10 →	+0.435	+0.097	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070234 vs SAMSN1_S23 — BRCA

Explore this scatter interactively →