Positive regulation of T cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of T cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDB2, MDM2, and RPS27L, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDB2 grouped by Positive regulation of T cell apoptotic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DDB2 →	-1.374	-1.460	.005	.008	3	7
SKIN	MDM2 →	-1.726	-1.690	<.001	<.001	3	7
LARGE_INTESTINE	RPS27L →	-1.309	-1.826	<.001	<.001	3	7
OVARY	BAX →	-1.179	-1.440	.006	<.001	3	6
SKIN	GDF15 →	-3.451	-1.493	<.001	<.001	3	6
SKIN	EDA2R →	-2.345	-1.329	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDB2 by Positive regulation of T cell apoptotic process activity — SOFT_TISSUE

Explore this box plot interactively →