Negative regulation of T cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of T cell apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, SAMSN1_S107, and SASH3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T cell apoptotic process activity versus RCSD1 in GBM (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RCSD1 →	+0.581	+0.095	<.001	<.001	3	10
UCEC	SAMSN1_S107 →	+0.954	+0.083	<.001	.001	3	10
GBM	SASH3 →	+0.530	+0.091	<.001	<.001	3	10
GBM	SEPTIN1 →	+1.052	+0.077	<.001	<.001	3	10
UCEC	SKAP2 →	+0.758	+0.066	<.001	.004	3	10
OV	SPN →	+0.658	+0.044	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070233 vs RCSD1 — GBM

Explore this scatter interactively →