Negative regulation of T cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of T cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD226, SIRPG, and NKG7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T cell apoptotic process activity versus CD226 in HNSC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CD226 →	+0.505	+0.776	<.001	<.001	3	7
BRCA	SIRPG →	+1.385	+0.491	<.001	<.001	3	7
BRCA	NKG7 →	+1.828	+0.495	<.001	<.001	3	6
BRCA	FASLG →	+1.083	+0.418	<.001	.001	3	6
GBM	LILRB2 →	+0.995	+0.815	<.001	<.001	3	6
GBM	MYO1F →	+0.800	+1.082	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070233 vs CD226 — HNSC

Explore this scatter interactively →