Negative regulation of T cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of T cell apoptotic process pathway is significantly associated with the drug response of multiple features, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are CAP-232, PLK_6522, and Venetoclax, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAP-232 grouped by Negative regulation of T cell apoptotic process-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CAP-232 →	-0.679	-0.651	.023	.012	3	3
OESOPHAGUS	PLK_6522 →	-0.696	-0.817	.012	.014	3	2
OESOPHAGUS	Venetoclax →	-0.478	-1.186	<.001	.009	3	2
OESOPHAGUS	Dactinomycin →	-0.426	-0.739	.035	.012	3	2
BLOOD_Lymphoma	IAP_7638 →	+0.537	+0.519	.012	.018	3	2
BLOOD_Lymphoma	MG-132 →	+0.739	+0.687	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAP-232 by Negative regulation of T cell apoptotic process activity — BLOOD_Lymphoma

Explore this box plot interactively →