Regulation of T cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Regulation of T cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAV8-6, RASAL3, and ARHGAP9, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell apoptotic process activity versus TRAV8-6 in LUAD (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TRAV8-6 →	+0.847	+0.875	<.001	.002	3	8
GBM	RASAL3 →	+0.757	+0.973	<.001	<.001	3	7
GBM	ARHGAP9 →	+0.906	+0.997	<.001	<.001	3	7
LUAD	PTPN7 →	+0.761	+1.152	<.001	<.001	3	7
LUAD	FCRL3 →	+0.776	+0.928	<.001	<.001	3	7
GBM	ZC3H12D →	+0.635	+0.914	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070232 vs TRAV8-6 — LUAD

Explore this scatter interactively →