Regulation of T cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of T cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GDF15, PHLDA3, and RPS27L, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GDF15 grouped by Regulation of T cell apoptotic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GDF15 →	-4.545	-1.504	<.001	.004	3	7
LARGE_INTESTINE	PHLDA3 →	-2.455	-1.424	<.001	<.001	3	6
OVARY	RPS27L →	-1.612	-1.156	<.001	.001	3	6
LARGE_INTESTINE	SESN1 →	-1.200	-0.973	<.001	<.001	3	6
OVARY	MDM2 →	-1.644	-1.202	<.001	<.001	3	5
OVARY	CDKN1A →	-2.511	-1.320	.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GDF15 by Regulation of T cell apoptotic process activity — SOFT_TISSUE

Explore this box plot interactively →