Regulation of T cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of T cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNPY4, CEP97, and KCTD7, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell apoptotic process activity versus CNPY4 in STOMACH (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CNPY4 →	-1.533	-0.202	<.001	<.001	3	10
BLOOD_Lymphoma	CEP97 →	-0.904	-0.135	<.001	<.001	3	10
BLOOD_Leukemia	KCTD7 →	-0.990	-0.114	<.001	<.001	3	10
LUNG_NSCLC_LUAD	TSC22D3 →	+1.962	+0.116	<.001	<.001	3	10
SOFT_TISSUE	CCDC77 →	-0.825	-0.093	<.001	<.001	3	10
BLOOD_Lymphoma	CWF19L1 →	-0.558	-0.126	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070232 vs CNPY4 — STOMACH

Explore this scatter interactively →