Regulation of T cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of T cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS3, MVP, and S100A6, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell apoptotic process activity versus LGALS3 in BONE (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	LGALS3 →	+4.191	+1.742	<.001	<.001	3	13
BLOOD_Lymphoma	MVP →	+2.215	+1.187	<.001	<.001	3	8
BONE	S100A6 →	+4.273	+1.742	.001	<.001	3	7
BLOOD_Leukemia	CTSA →	+1.085	+0.961	<.001	.009	3	6
BONE	SUMF1 →	+1.411	+1.742	<.001	<.001	3	5
BONE	DOCK5 →	+2.985	+1.913	.009	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070232 vs LGALS3 — BONE

Explore this scatter interactively →