Regulation of T cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of T cell apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LGALS3, ACTN4, and CAPNS1, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell apoptotic process activity versus LGALS3 in LUNG_NSCLC_LUSC (Pearson r = 0.79).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LGALS3 →	+4.396	+1.944	.002	.001	3	18
BONE	ACTN4 →	+1.843	+1.627	<.001	<.001	3	9
BLOOD_Lymphoma	CAPNS1 →	+0.707	+0.918	<.001	<.001	3	7
BONE	MVP →	+2.112	+1.426	<.001	.001	3	7
BONE	S100A6 →	+4.298	+1.549	<.001	<.001	3	7
LUNG_NSCLC_LUSC	PRPF4 →	-0.570	-2.028	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070232 vs LGALS3 — LUNG_NSCLC_LUSC

Explore this scatter interactively →