T cell apoptotic process

Across TCGA patient cohorts, RNA activity of the T cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP9, UBASH3A, and JAK3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell apoptotic process activity versus ARHGAP9 in GBM (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGAP9 →	+0.641	+0.160	<.001	<.001	3	7
GBM	UBASH3A →	+0.372	+0.173	<.001	<.001	3	7
GBM	JAK3 →	+0.876	+0.202	<.001	<.001	3	6
GBM	DOCK2 →	+0.706	+0.186	<.001	<.001	3	6
GBM	PARVG →	+0.631	+0.177	<.001	<.001	3	6
LUAD	ARHGAP25 →	+0.364	+0.180	.008	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070231 vs ARHGAP9 — GBM

Explore this scatter interactively →