Positive regulation of lymphocyte apoptotic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of lymphocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBP5, TAP2, and IL4I1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lymphocyte apoptotic process activity versus GBP5 in LUAD (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GBP5 →	+0.790	+0.385	<.001	<.001	3	6
LSCC	TAP2 →	+0.765	+0.875	<.001	<.001	3	6
LUAD	IL4I1 →	+0.955	+0.368	<.001	.001	3	5
LUAD	NKG7 →	+0.819	+0.527	.001	.001	3	5
LUAD	CXCL9 →	+1.149	+0.355	<.001	<.001	3	5
LSCC	NLRC5 →	+0.802	+0.871	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070230 vs GBP5 — LUAD

Explore this scatter interactively →