Positive regulation of lymphocyte apoptotic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of lymphocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN1A, GDF15, and PHLDA3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDKN1A grouped by Positive regulation of lymphocyte apoptotic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDKN1A →	-3.164	-1.623	<.001	<.001	3	9
SOFT_TISSUE	GDF15 →	-3.963	-1.874	<.001	<.001	3	7
SKIN	PHLDA3 →	-2.411	-1.540	<.001	<.001	3	7
CNS	RPS27L →	-1.460	-1.367	<.001	.001	3	7
SOFT_TISSUE	DDB2 →	-1.291	-1.167	.001	.004	3	7
SKIN	MDM2 →	-1.651	-1.461	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDKN1A by Positive regulation of lymphocyte apoptotic process activity — LARGE_INTESTINE

Explore this box plot interactively →