Positive regulation of lymphocyte apoptotic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of lymphocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LTBP4, ARHGAP24, and ST3GAL2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lymphocyte apoptotic process activity versus LTBP4 in LUNG_NSCLC_LUAD (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LTBP4 →	+1.426	+2.098	.008	.001	3	2
LARGE_INTESTINE	ARHGAP24 →	-2.075	-0.526	.002	.009	3	2
LARGE_INTESTINE	ST3GAL2 →	+2.110	+0.603	.006	.001	3	2
CNS	AP3D1 →	-1.085	-2.275	.007	.001	3	2
BLOOD_Lymphoma	RRP36 →	+1.244	+1.866	.006	<.001	3	2
BLOOD_Lymphoma	PRIM2 →	+0.868	+1.326	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070230 vs LTBP4 — LUNG_NSCLC_LUAD

Explore this scatter interactively →