Regulation of lymphocyte apoptotic process

Across TCGA patient cohorts, RNA activity of the Regulation of lymphocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WAS, ADGRE2, and FCGR1B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lymphocyte apoptotic process activity versus WAS in HNSC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	WAS →	+0.540	+0.825	.009	.003	3	7
LUAD	ADGRE2 →	+0.544	+0.917	.002	<.001	3	6
UCEC	FCGR1B →	+0.566	+0.865	.001	.002	3	6
LSCC	LILRB1 →	+0.582	+0.681	<.001	.003	3	6
LSCC	TLR8 →	+0.761	+0.739	<.001	.002	3	6
GBM	MYO1F →	+0.579	+0.317	.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070228 vs WAS — HNSC

Explore this scatter interactively →