Regulation of lymphocyte apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of lymphocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS27L, CDKN1A, and SESN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS27L grouped by Regulation of lymphocyte apoptotic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RPS27L →	-0.985	-0.793	.006	.002	3	4
SKIN	CDKN1A →	-2.483	-1.056	<.001	.003	3	4
OVARY	SESN1 →	-1.469	-1.570	<.001	<.001	3	4
OVARY	BBC3 →	-1.238	-0.979	<.001	<.001	3	4
LUNG_NSCLC_LUAD	ETV6 →	-0.838	-0.577	<.001	.002	3	3
CNS	EHBP1 →	-0.807	-0.773	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS27L by Regulation of lymphocyte apoptotic process activity — OVARY

Explore this box plot interactively →