Regulation of lymphocyte apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of lymphocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSC22D3, GTSE1, and PUS7, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lymphocyte apoptotic process activity versus TSC22D3 in OVARY (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TSC22D3 →	+2.122	+0.078	.002	.004	2	12
BLOOD_Leukemia	GTSE1 →	-1.102	-0.088	<.001	<.001	3	11
BLOOD_Lymphoma	PUS7 →	-1.158	-0.110	<.001	<.001	3	11
SOFT_TISSUE	ESPL1 →	-1.182	-0.108	<.001	<.001	3	11
BONE	KIF11 →	-1.258	-0.063	.007	.009	3	11
BLOOD_Lymphoma	SCML2 →	-2.659	-0.085	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070228 vs TSC22D3 — OVARY

Explore this scatter interactively →