Lymphocyte apoptotic process

Across TCGA patient cohorts, RNA activity of the Lymphocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD72, IRF1, and OVOL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphocyte apoptotic process activity versus CD72 in LSCC (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CD72 →	+0.705	+0.179	<.001	<.001	3	5
LSCC	IRF1 →	+0.777	+0.199	<.001	<.001	3	5
LSCC	OVOL2 →	-0.532	-0.149	.005	<.001	3	5
BRCA	AQR →	-0.418	-0.466	<.001	.003	3	5
LUAD	ZNF830 →	-0.244	-0.341	.002	.004	3	5
COAD	CD3G →	+0.404	+0.468	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070227 vs CD72 — LSCC

Explore this scatter interactively →