Lymphocyte apoptotic process

Across TCGA cell cohorts, RNA activity of the Lymphocyte apoptotic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJA3, C7orf57, and RPL10L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAJA3 grouped by Lymphocyte apoptotic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DNAJA3 →	-0.298	-0.160	.001	<.001	3	4
SKIN	C7orf57 →	+0.287	+1.065	.007	.003	3	4
SKIN	RPL10L →	-0.215	-1.327	.004	.002	3	4
LUNG_NSCLC_LUAD	ST8SIA1 →	+0.155	+0.133	.004	.004	3	3
LUNG_NSCLC_LUAD	GPR156 →	-0.148	-0.166	<.001	.007	3	3
LUNG_SCLC	UMPS →	-0.195	-0.184	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAJA3 by Lymphocyte apoptotic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →