Protein auto-ADP-ribosylation

Across TCGA patient cohorts, RNA activity of the Protein auto-ADP-ribosylation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SASH3_S97, GDPD3, and SLC16A3_S436, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein auto-ADP-ribosylation activity versus SASH3_S97 in HNSC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SASH3_S97 →	+0.487	+0.057	.002	.002	3	6
HNSC	GDPD3 →	-0.581	-0.068	<.001	.001	3	6
GBM	SLC16A3_S436 →	-0.470	-0.053	.004	<.001	3	5
UCEC	DPYD →	+0.493	+0.071	<.001	.005	3	5
LSCC	RPL26 →	-0.438	-0.064	<.001	<.001	3	5
CCRCC	CTHRC1 →	+0.465	+0.018	.009	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070213 vs SASH3_S97 — HNSC

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