Protein auto-ADP-ribosylation

Across TCGA patient cohorts, RNA activity of the Protein auto-ADP-ribosylation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM248, PIK3C2A, and PGF, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein auto-ADP-ribosylation activity versus TMEM248 in BRCA (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TMEM248 →	-0.270	-0.428	.001	.001	3	3
BRCA	PIK3C2A →	-0.586	-0.572	.001	.001	3	3
LSCC	PGF →	-0.511	-0.432	.008	.002	3	3
BRCA	AKAP9 →	-0.531	-0.436	<.001	<.001	3	3
BRCA	CALU →	-0.421	-0.569	.003	<.001	3	3
BRCA	PRRG3 →	-0.230	-0.439	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070213 vs TMEM248 — BRCA

Explore this scatter interactively →