Protein auto-ADP-ribosylation

Across TCGA cell cohorts, RNA activity of the Protein auto-ADP-ribosylation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZMAT1, GDI2, and SMIM3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZMAT1 grouped by Protein auto-ADP-ribosylation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ZMAT1 →	+1.577	+1.475	.001	<.001	3	4
LUNG_NSCLC_LUAD	GDI2 →	-0.677	-0.639	<.001	.003	3	4
LIVER	SMIM3 →	-2.105	-1.562	<.001	<.001	3	4
LIVER	PGM1 →	-1.259	-1.477	.002	<.001	3	4
PANCREAS	WBP2NL →	+0.465	+1.122	.005	<.001	3	4
URINARY_TRACT	LRRC37B →	+1.550	+1.844	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZMAT1 by Protein auto-ADP-ribosylation activity — KIDNEY

Explore this box plot interactively →