Protein trimerization

Across TCGA patient cohorts, RNA activity of the Protein trimerization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP1R18_S224, PXDN, and C1QC, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein trimerization activity versus PPP1R18_S224 in LSCC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PPP1R18_S224 →	+0.536	+0.076	<.001	<.001	3	8
BRCA	PXDN →	+0.633	+0.092	<.001	<.001	3	7
COAD	C1QC →	+0.544	+0.047	.006	.001	3	7
BRCA	FSCN1 →	+0.520	+0.051	<.001	<.001	3	7
COAD	MNDA →	+0.754	+0.055	.001	<.001	3	7
LSCC	THEMIS2 →	+0.390	+0.100	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070206 vs PPP1R18_S224 — LSCC

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