Protein trimerization

Across TCGA cell cohorts, RNA activity of the Protein trimerization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF709, TAP1, and ZNF347, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein trimerization activity versus ZNF709 in LUNG_SCLC (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZNF709 →	-0.685	-0.297	<.001	.002	3	5
LUNG_SCLC	TAP1 →	+2.199	+0.284	.007	.003	3	5
CNS	ZNF347 →	-1.434	-0.203	.001	.008	3	4
LUNG_SCLC	RASSF8 →	+2.325	+0.343	<.001	<.001	3	4
BLOOD_Myeloma	AS3MT →	+0.681	+0.468	.004	.003	3	4
BLOOD_Lymphoma	ZNF606 →	-1.544	-0.233	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070206 vs ZNF709 — LUNG_SCLC

Explore this scatter interactively →