Regulation of establishment of protein localization to chromosome

Across TCGA patient cohorts, RNA activity of the Regulation of establishment of protein localization to chromosome pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOLLIP, DEK, and ANKFY1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of establishment of protein localization to chromosome activity versus TOLLIP in HNSC (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TOLLIP →	-0.264	-0.098	<.001	.001	3	6
HNSC	DEK →	+0.327	+0.090	<.001	<.001	3	6
GBM	ANKFY1 →	-0.157	-0.026	.001	.002	3	6
HNSC	MINK1 →	-0.354	-0.077	<.001	.008	3	6
UCEC	PACSIN2 →	-0.333	-0.096	<.001	<.001	3	6
COAD	ATRX →	+0.273	+0.032	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070202 vs TOLLIP — HNSC

Explore this scatter interactively →