Regulation of establishment of protein localization to chromosome

Across TCGA patient cohorts, RNA activity of the Regulation of establishment of protein localization to chromosome pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB8OS, SENP1, and PHTF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of establishment of protein localization to chromosome activity versus ZBTB8OS in COAD (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ZBTB8OS →	-0.499	-0.140	<.001	<.001	3	4
CCRCC	SENP1 →	-0.230	-0.113	<.001	<.001	3	4
COAD	PHTF1 →	-0.281	-0.082	<.001	.002	3	4
BRCA	ITGB1BP1 →	-0.309	-0.131	.002	.001	3	4
COAD	CDKN2C →	-0.527	-0.091	<.001	<.001	3	4
COAD	SNRNP27 →	-0.379	-0.102	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070202 vs ZBTB8OS — COAD

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