Establishment of protein localization to telomere

Across TCGA patient cohorts, RNA activity of the Establishment of protein localization to telomere pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NOL10, UBTF_S484, and WDR36, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of protein localization to telomere activity versus NOL10 in BRCA (Pearson r = -0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NOL10 →	+0.349	+0.030	.002	.001	3	7
LSCC	UBTF_S484 →	+0.997	+0.056	<.001	<.001	3	6
HNSC	WDR36 →	+0.203	+0.061	.003	.007	3	6
HNSC	XPO5 →	+0.492	+0.080	<.001	<.001	3	6
HNSC	DDX47 →	+0.492	+0.075	<.001	<.001	3	6
LSCC	NKTR_S463 →	+0.507	+0.044	<.001	<.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070200 vs NOL10 — BRCA

Explore this scatter interactively →