Establishment of protein localization to telomere

Across TCGA patient cohorts, RNA activity of the Establishment of protein localization to telomere pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FXR1, HNRNPR, and RAD51C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of protein localization to telomere activity versus FXR1 in COAD (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FXR1 →	-0.342	-0.117	<.001	.008	3	5
CCRCC	HNRNPR →	-0.233	-0.103	<.001	.003	3	4
HNSC	RAD51C →	-0.390	-0.086	.001	.003	3	4
HNSC	WDPCP →	-0.478	-0.104	<.001	<.001	3	4
HNSC	IGSF11 →	-0.695	-0.097	.001	<.001	3	4
HNSC	TTC14 →	-0.553	-0.128	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070200 vs FXR1 — COAD

Explore this scatter interactively →