Establishment of protein localization to chromosome

Across TCGA cell cohorts, RNA activity of the Establishment of protein localization to chromosome pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TET3, TSPAN15, and STEAP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of protein localization to chromosome activity versus TET3 in PANCREAS (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TET3 →	+0.893	+0.188	<.001	.002	3	5
PANCREAS	TSPAN15 →	+1.609	+0.192	.006	.007	3	5
LIVER	STEAP3 →	-2.061	-0.204	.001	.004	3	4
SOFT_TISSUE	RILPL2 →	-1.001	-0.222	.002	.002	3	4
LUNG_NSCLC_LUSC	SLC41A2 →	-1.521	-0.254	.004	.001	3	4
BLOOD_Leukemia	LMNA →	-2.167	-0.113	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070199 vs TET3 — PANCREAS

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