Meiotic attachment of telomere to nuclear envelope

Across TCGA patient cohorts, RNA activity of the Meiotic attachment of telomere to nuclear envelope pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CXorf38, RGS3_S1007, and PARP14, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic attachment of telomere to nuclear envelope activity versus CXorf38 in LSCC (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CXorf38 →	-0.262	-0.102	<.001	<.001	3	7
LSCC	RGS3_S1007 →	-0.723	-0.091	<.001	<.001	3	6
LSCC	PARP14 →	-0.452	-0.102	<.001	<.001	3	6
LSCC	FOXK1 →	+0.323	+0.074	<.001	<.001	3	6
LSCC	RNF213 →	-0.451	-0.098	<.001	<.001	3	5
LSCC	SSH2_S784 →	-0.338	-0.077	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070197 vs CXorf38 — LSCC

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