Meiotic attachment of telomere to nuclear envelope

Across TCGA patient cohorts, RNA activity of the Meiotic attachment of telomere to nuclear envelope pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUN1, SNRPB2, and PZP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic attachment of telomere to nuclear envelope activity versus SUN1 in LSCC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SUN1 →	+0.749	+0.737	.003	.001	3	5
GBM	SNRPB2 →	+0.430	+0.734	.004	.003	3	3
HNSC	PZP →	-0.937	-0.731	<.001	<.001	3	3
LSCC	MRPS17 →	+0.860	+0.658	.004	.005	3	3
CCRCC	MALSU1 →	+0.695	+1.032	.008	.003	3	3
CCRCC	PAXIP1 →	+0.482	+0.992	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070197 vs SUN1 — LSCC

Explore this scatter interactively →