Meiotic attachment of telomere to nuclear envelope

Across TCGA cell cohorts, RNA activity of the Meiotic attachment of telomere to nuclear envelope pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STEAP1B, CSF1, and SMIM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STEAP1B grouped by Meiotic attachment of telomere to nuclear envelope-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	STEAP1B →	+3.795	+1.784	.003	.005	2	5
LUNG_SCLC	CSF1 →	+1.659	+0.843	<.001	.002	2	4
LUNG_SCLC	SMIM1 →	+1.371	+1.002	.004	.005	3	3
SKIN	SNPH →	+0.906	+0.946	<.001	.003	3	3
LUNG_NSCLC_LUAD	MXRA7 →	+1.550	+1.320	.004	<.001	3	3
LUNG_NSCLC_LUSC	ATXN7L3B →	-0.754	-1.333	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STEAP1B by Meiotic attachment of telomere to nuclear envelope activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →