Synaptonemal complex organization

Across TCGA cell cohorts, RNA activity of the Synaptonemal complex organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO27, NUP93, and SLC1A3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptonemal complex organization activity versus FBXO27 in BLOOD_Myeloma (Pearson r = -0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	FBXO27 →	-2.223	-0.293	.001	.008	3	4
BLOOD_Leukemia	NUP93 →	+0.420	+0.211	.007	.003	3	4
OESOPHAGUS	SLC1A3 →	-3.602	-0.227	<.001	.003	3	3
OESOPHAGUS	ISCA2 →	-0.945	-0.299	.002	<.001	3	3
OESOPHAGUS	MARCKSL1 →	+1.565	+0.232	<.001	.002	3	3
LARGE_INTESTINE	OTUD7A →	+0.630	+0.221	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070193 vs FBXO27 — BLOOD_Myeloma

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