Chromosome organization involved in meiotic cell cycle

Across TCGA cell cohorts, RNA activity of the Chromosome organization involved in meiotic cell cycle pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP4R1, TMSB10, and SEH1L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP4R1 grouped by Chromosome organization involved in meiotic cell cycle-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PPP4R1 →	+0.691	+0.212	.002	.001	3	4
LUNG_NSCLC_LUSC	TMSB10 →	+1.636	+0.286	.001	.004	2	5
PANCREAS	SEH1L →	+1.217	+0.237	.002	.005	3	4
LIVER	NUDT4 →	-1.171	-0.277	.005	.001	3	3
LARGE_INTESTINE	ZMYND8 →	-1.064	-0.242	<.001	<.001	3	3
LARGE_INTESTINE	CORO2A →	-1.077	-0.374	.002	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP4R1 by Chromosome organization involved in meiotic cell cycle activity — PANCREAS

Explore this box plot interactively →