Chromosome organization involved in meiotic cell cycle

Across TCGA cell cohorts, RNA activity of the Chromosome organization involved in meiotic cell cycle pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM222B, PDPN, and MADD, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM222B grouped by Chromosome organization involved in meiotic cell cycle-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	FAM222B →	-0.203	-1.600	.006	<.001	3	4
LUNG_SCLC	PDPN →	-0.155	-0.608	.005	.007	3	4
SKIN	MADD →	+0.148	+0.803	.001	.003	3	3
LUNG_NSCLC_LUAD	HEPH →	+0.158	+0.655	.002	.002	3	3
LARGE_INTESTINE	NBN →	-0.159	-0.859	.006	.005	3	3
LARGE_INTESTINE	POP4 →	-0.478	-1.633	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM222B by Chromosome organization involved in meiotic cell cycle activity — LIVER

Explore this box plot interactively →