Kynurenine metabolic process

Across TCGA patient cohorts, RNA activity of the Kynurenine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the ESCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNXB, INMT, and KYAT1, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Kynurenine metabolic process activity versus TNXB in ESCA (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	TNXB →	-1.141	-0.032	<.001	<.001	3	19
THCA	INMT →	-1.009	-0.030	<.001	<.001	3	17
ESCA	KYAT1 →	+0.733	+0.061	<.001	<.001	3	17
THYM	GGT5 →	-1.431	-0.041	<.001	<.001	3	17
UVM	MS4A7 →	-1.067	-0.042	<.001	<.001	3	16
THYM	CYTH3 →	-0.801	-0.032	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070189 vs TNXB — ESCA

Explore this scatter interactively →