Kynurenine metabolic process

Across TCGA patient cohorts, RNA activity of the Kynurenine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GBP5, STAT1, and GBP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Kynurenine metabolic process activity versus GBP5 in BRCA (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GBP5 →	+0.676	+0.049	.003	.003	3	7
BRCA	STAT1 →	+0.499	+0.050	<.001	.002	3	6
HNSC	GBP1 →	+0.681	+0.072	.001	<.001	2	7
PDAC	IDO1 →	+0.851	+0.060	<.001	<.001	3	6
HNSC	KYNU →	+1.010	+0.091	<.001	<.001	3	6
BRCA	RIDA →	-0.401	-0.041	.002	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070189 vs GBP5 — BRCA

Explore this scatter interactively →