Kynurenine metabolic process

Across TCGA patient cohorts, RNA activity of the Kynurenine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRF1, ETV7, and IL18RAP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Kynurenine metabolic process activity versus PRF1 in HNSC (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PRF1 →	+0.939	+0.121	<.001	<.001	3	7
BRCA	ETV7 →	+1.121	+0.128	<.001	.008	3	6
GBM	IL18RAP →	+0.721	+0.227	<.001	.001	3	6
LSCC	S1PR4 →	+0.866	+0.178	<.001	<.001	3	6
BRCA	LILRB2 →	+0.940	+0.193	<.001	<.001	3	6
LSCC	WARS1 →	+0.792	+0.120	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070189 vs PRF1 — HNSC

Explore this scatter interactively →