Kynurenine metabolic process

Across TCGA cell cohorts, RNA activity of the Kynurenine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NMRK1, OTOP2, and DDX20, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Kynurenine metabolic process activity versus NMRK1 in LUNG_NSCLC_LUAD (Pearson r = -0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NMRK1 →	-1.466	-1.813	.005	<.001	3	2
LUNG_NSCLC_LUAD	OTOP2 →	+0.140	+1.508	.006	.005	3	2
LUNG_NSCLC_LUAD	DDX20 →	+0.773	+1.928	.005	<.001	3	2
BLOOD_Lymphoma	ACTR3C →	+1.542	+0.228	.002	.006	3	2
BLOOD_Lymphoma	JADE2 →	+1.216	+0.228	.002	.006	3	2
BLOOD_Lymphoma	SIRT6 →	+0.616	+0.228	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070189 vs NMRK1 — LUNG_NSCLC_LUAD

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