Kynurenine metabolic process

Across TCGA cell cohorts, RNA activity of the Kynurenine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FAM136A, QARS1, and KRT5, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Kynurenine metabolic process activity versus FAM136A in LUNG_NSCLC_LUAD (Pearson r = 0.69).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FAM136A →	+1.452	+1.630	.009	.009	3	2
KIDNEY	QARS1 →	+0.603	+0.636	<.001	<.001	3	2
KIDNEY	KRT5 →	-5.085	-0.666	.002	<.001	3	2
KIDNEY	TRMT2A →	+1.229	+0.506	.006	.003	3	2
BONE	UBXN7 →	+0.750	+2.102	.007	<.001	3	2
BONE	MICOS10 →	+0.626	+2.031	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070189 vs FAM136A — LUNG_NSCLC_LUAD

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