Positive regulation of enamel mineralization

Across TCGA patient cohorts, RNA activity of the Positive regulation of enamel mineralization pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTCH1, STK38, and NRG4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of enamel mineralization activity versus MTCH1 in OV (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MTCH1 →	-0.677	-0.346	.001	.007	3	3
PDAC	STK38 →	-0.333	-0.610	<.001	<.001	3	3
PDAC	NRG4 →	+0.595	+0.734	.003	.001	3	3
UCEC	HSD11B1-AS1 →	-0.557	-0.587	.007	.005	3	3
LUAD	LINC02688 →	+0.890	+0.307	.009	.005	3	3
LSCC	TTC5 →	-0.376	-0.309	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070175 vs MTCH1 — OV

Explore this scatter interactively →