Positive regulation of enamel mineralization

Across TCGA cell cohorts, RNA activity of the Positive regulation of enamel mineralization pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC31A2, EPHA2, and WDR5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC31A2 grouped by Positive regulation of enamel mineralization-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SLC31A2 →	-1.637	-1.295	.001	.004	3	4
CNS	EPHA2 →	-1.167	-0.811	<.001	<.001	3	4
PANCREAS	WDR5 →	-1.031	-1.253	.005	.006	3	4
CNS	MYCBP →	-0.707	-0.954	<.001	<.001	3	4
BONE	BORA →	-0.637	-0.575	.003	<.001	3	4
BONE	JMJD6 →	-0.904	-0.627	.004	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC31A2 by Positive regulation of enamel mineralization activity — SOFT_TISSUE

Explore this box plot interactively →