Regulation of enamel mineralization

Across TCGA cell cohorts, RNA activity of the Regulation of enamel mineralization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TJP3, NCAPG2, and TTI1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TJP3 grouped by Regulation of enamel mineralization-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TJP3 →	+2.481	+1.468	.004	<.001	3	5
SOFT_TISSUE	NCAPG2 →	-0.879	-1.715	.008	.002	3	5
SOFT_TISSUE	TTI1 →	-0.839	-1.788	.006	<.001	3	4
KIDNEY	FOXJ2 →	-0.896	-1.083	.002	.005	3	4
LARGE_INTESTINE	MBLAC2 →	+0.805	+1.480	<.001	<.001	3	4
BREAST	ZNF580 →	+1.007	+1.285	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TJP3 by Regulation of enamel mineralization activity — PANCREAS

Explore this box plot interactively →